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29 Apr 2014:
IBM (NYSE: IBM) today announced a collaboration with Coriell Life Sciences, a provider of genetic analysis at point of care, and CareKinesis, Inc., a Medication Risk Mitigation® pharmacy services firm, to bring personalized medicine to the elderly based on analyzing and storing genetic data in a secure cloud environment.
Using SoftLayer, an IBM Company, Coriell Life Sciences, in collaboration with IBM and CareKinesis, is launching an initiative with Program for All Inclusive Care of the Elderly (PACE) clients, which cares for more than 5,000 seniors, helping to enhance medication safety by better understanding how high-risk individuals respond to specific medications and drug treatments. Currently, about three out of four older Americans have multiple chronic health conditions. Many of these patients are being treated with drugs that may work at odds with each other – the medication being used for one condition can actually make another condition worse.
By 2030, one in five Americans will be over age 65. As a result, increasing healthcare costs and the healthcare system are just beginning to feel the burden.
“The goal of personalized medicine is to individualize healthcare by using knowledge of patients’ health history, behaviors, environments, and, most recently, individual genetic makeup when making clinical decisions,” explained CareKinesis CEO Calvin H. Knowlton, BSPharm, MDiv, PhD. “This initiative will allow physicians to collaborate with CareKinesis pharmacists to access a patient’s genetic data to better understand what drug treatments are likely to be responded to, thus reducing medication-related problems and hospital visits, while decreasing the individual’s overall healthcare costs.”
Overcoming the Big Data Challenge
Working with genetic data presents massive challenges for both data storage and privacy protection. A whole human genome produces more than three billion points of data for a single individual. To address these issues, Coriell Life Sciences turned to a cloud storage service based on SoftLayer.
In collaboration with IBM, Coriell Life Sciences built a scalable, cloud-based solution that safely and cost-effectively stores data in Coriell Life Sciences’ GeneVault. The GeneVault stores and manages millions of genetic data points. This data is then interpreted and shared with physicians through CareKinesis who layer additional medication management decision factors into a holistic tool for doctors within PACE organizations.
Under the strict privacy controls of the interconnected CareKinesis and Coriell Life Sciences systems, physicians, healthcare providers and medical experts can access a patient’s genomic interpretation via any web connected device. For example, a cardiologist may consider prescribing a popular blood-thinning drug for an elderly man, but may be concerned about the potential for an adverse reaction. The PACE Team decides to conduct a test to assess if the participant will respond to the medication being considered. The test is run by swabbing the inside of the patient’s cheek to collect a tiny amount of genetic material, which goes to Coriell Life Sciences for testing. Results are analyzed and interpreted for their impact on drug response. The resulting report is then transmitted to the doctor giving guidance on whether the patient can safely use the drug. CareKinesis supports the process by making pharmacotherapy recommendations based on these results. The data can be used at any time it is needed in the future for pharmacotherapy prescribing decisions.
“This approach of treating conditions “one at a time” even if the treatments might conflict with one another has been common in medicine, in part because little information exists to guide practitioners in how to consider this problem, weigh alternatives and identify different options. Better understanding of an individual’s genome can lead to a more effective dosage regimen,” said Scott Megill, CEO of Coriell Life Sciences. “Now with the collaboration with IBM and CareKinesis, personalized medicine is presenting many new options to this growing demographic. The combination of cloud and mobile is making a healthcare ecosystem possible with the patient center stage, delivering health services more efficiently.”
For more information on Coriell Life Sciences, visit http://www.coriell.com/
For more information on CareKinesis, visit http://www.carekinesis.com/
For more information on IBM Healthcare, visit www.ibm.com/industries/healthcare/
For more information about cloud offerings from IBM, visit http://www.ibm.com/cloud.
For more information on IBM Impact, visit www.ibm.com/press/ibmimpact2014.
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